![]() Novartis AG’s Adakveo and Emmaus Life Sciences Inc.’s Endari are used to treat painful episodes called crises that arise when misshapen blood cells clog vessels, robbing them of oxygen and damaging tissues. Tosin Ola, a nurse from San Marcos, California with sickle cell disease, describes the pain of a crisis like the feeling of 1,000 hammers smashing her bones or of the burning sensation of a hot curling iron inside her body. There are only four sickle cell drugs cleared in the US, including hydroxyurea and Global Blood’s Oxbyrta, which stops blood cells from changing shape. Some patients undergo regular transfusions to minimize the proportion of sickled cells. Treatment options remain scant for the blood disorder. A limited number of patients are eligible to receive a transplant of a sibling’s healthy bone marrow, where blood cells are made, that can cure them. Cystic fibrosis affects about 100,000 in developed countries compared to about 150,000 sickle cell patients in the US and Europe, said Cantor Fitzgerald analyst Li Watsek, and there are millions more people with sickle cell in sub-Saharan Africa, India, the Middle East and the Mediterranean. Between 20, the US government spent less than one-third as much money on sickle cell as it did on cystic fibrosis, a rare disease that most often afflicts White people, according to a 2020 study published in JAMA Network Open, and cystic fibrosis advocacy groups spent 75 times as much as sickle cell groups over the same period. “A lot of companies said, ‘Huh, there’s a whole open field here where nothing works we should find something that works,’” said Julie Kanter, director of the adult sickle cell clinic at the University of Alabama at Birmingham.īut the fact remains that historical investment in sickle cell disease has been comparatively low. Before its purchase of Global Blood, Pfizer was pursuing its own drugs for sickle cell but one failed and the other wasn't any better than Global Blood's Oxbryta. The late bloom of therapies is in part due to scientists gaining a better understanding of the disease and new technologies to tackle it, said Seng Cheng, chief scientific officer of rare diseases at Pfizer. Some of the emerging treatments use cutting-edge science like Crispr, a tool for editing genes. Today, roughly 30 drugs are in human trials with the same number in the early phases of research, according to a Bloomberg analysis of SpringerNature data. In about a decade, sickle cell has gone from an overlooked affliction to one with so many drugs in development it’s hard to keep track. Just a few years ago, the only drug was hydroxyurea, a cancer therapy that also prevents blood cells from deforming. The drug giant’s purchase of Global Blood Therapeutics Inc. is the latest lap in a race to take on the inherited disorder in which a genetic mutation causes red blood cells to contort into crescents instead of full moons, preventing them from functioning properly. Global Blood makes Oxbryta, one of the few drugs approved to treat the disease, and is developing others. Finally big drugmakers are taking notice, culminating with Pfizer Inc.’s $5.4 billion acquisition of one of the more promising drugs to treat sickle cell disease. (Bloomberg) - It’s been more than seventy years since a renowned scientist first described the cause of a painful, sometimes lethal disorder that in the US afflicts mainly Black people.
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![]() Here are some of the sections I just saw when opening the app and going to the Home page:Įverything until and including Because You Added was music I was interested in - TIDAL had a great selection of good tracks. They displayed more songs that I was actually interested in, and it was overall easier to find songs in the genres I liked that I had not yet listened to. I found the discovery features of TIDAL better than Qobuz. Which app has a better layout? Is Quboz or TIDAL easier to navigate and use? Qobuz Interesting Post: Best Crunchyroll Alternatives Qobuz vs TIDAL: Layout And Ease Of Use Even though, when it comes to signing up for a free trial, it gets more complicated, as there are two main plans with different audio quality. Overall, the TIDAL signup process is better than with Qobuz. However, those suggestions did not stop there I was also shown popular TIDAL mixes unrelated to the specific artists I chose. Not only that but I was actually shown suggestions related to those artists once I arrived at the homepage of the app. Under Latin, I could select artists like Bad Bunny and Becky G. Instead of selecting entire genres during the signup process, I was shown popular artists from many genres.įor example, under Country, I could select artists such as Johnny Cash, Waylon Jennings, and The Highwaymen. Overall, its signup process is quite better than for the latter. TIDAL is just similarly easy to sign up for. I will talk about features, pricing, difference in Audio quality offered, and more. In today’s contrast, I will be comparing Qobuz and TIDAL, as the streaming services that they are in order to help you figure out which one could be the best. If you pay attention, you can notice it, even if you are not an audiophile. With the mention of that, we have to remember that not everyone will notice the difference between an ultra high resolution and a slightly lower streaming service, even though the difference is definitely there. The aim is to bring the aesthetics of analog music into the digital world and become the only address for all your music. It uses a large database when sorting and connecting your music, automatically complements album covers, information about the artist, lyrics and other things. Roon, as a system, is an all-round tool that combines music streaming, digitized music, downloaded and physical music purchases and more. One major similarity between these two streaming services is their dedicated music server system i.e. They’re not that expensive, but their aim is to provide the best audio quality for streaming music so you can listen to music without experiencing any coloration or distortion. Two high-fidelity streaming services are Quboz and TIDAL. The reality is that the sound you will get from Spotify or another streaming service will usually be slightly distorted. ![]() ![]() There are subtle differences in sound quality and frequency that only audiophiles pay attention to. With such people, the urge for good music is greater than with the normal listener. While you may not notice the difference between Spotify and a streaming service like Qobuz, you can bet that an audiophile definitely does. They aim to reproduce the sound of live music in their own homes or on the go. They are always enthusiastic about hi-fi (high fidelity) sound. However, audiophiles are a different breed. In fact, to most people, music is just sound. Many other music fanatics will not notice much of a difference between the audio and sound quality offered by any of the above-mentioned streaming services or even the higher resolution streaming apps. Speaking of audiophiles, the “loving listening” of pure audio and good audio quality is not an objective designation in the narrower sense, but rather subjectively to be interpreted for the respective person. While brands like Spotify, iTunes, YouTube Music, and Amazon Prime Music are some of the most well-known in the music streaming industry, there is a certain niche of streaming services popular specifically among audiophiles. Now, whenever you highlight a link, PopClip will appear with a new lightning bolt icon that automatically sends the URL to Short Menu for processing, giving you a perfect shortened vanity URL to use. You can install up to 25 extensions at a time and rearrange them by dragging their icons in the PopClip system menu, which orders how they appear in the selection or paste pop-up bar. Simply double-click the file and PopClip will automatically install and activate it. Just about every popular productivity app, browser, and search site is included for starters. PDF, PPT, WORD etc.), the translated results will then be automatically displayed before you. Google Translate API Script ![]() This one is free, open source and it's full of HTML5 goodness. However, the desktop apps are often bloated and not intuitive, and most web apps charge you for premium features. // verse trim(getenv('POPCLIPTEXT')) qKJV getenv('POPCLIPOPTIONBIBLEKJV') qThaiKJV getenv('POPCLIPOPTIONBIBLETHAIKJV') keycode intval(getenv('POPCLIPMODIFIERFLAGS')) results '' // // If the preference is set to KJV or the command key // is pressed, then get the verse from the English KJV // and add it to the result. There are many mind mapping applications out there. ![]() It lets you create neat looking mind maps in the browser.ĭid you know that it is still available offline? You can use the app wherever you are, there is no need for an internet connection, everything happens inside your browser on your machine. From Madrid - A tech tip about why small gains from tiny software utilities add up to big time-savings over the long term, specifically tools like Hazel, PopClip, BetterTouchTool, Paste, and TextExpander. This is a prototype of an HTML5 based mind mapping application. Add a Google Translate extension to PopClip and now you can select some. PopClip adalah salah satu aplikasi favorit kami di Mactuts+ dan salah satu alasan mengapa ini mendukung. The project is now open sourced and on Github for developer contribution, we expect great things. Automatic language translation in Safari is superb, but it has a limited number. Membuat Custom Extension Anda Sendiri untuk PopClip. We give it two huge thumbs up and highly recommend you giving it a try, go to not doctor Richard (lol). You can save your files in the cloud, It supports Google, Dropbox and more, or you could save the file locally (JSON), there is even a browser-based experimental saving option.īy the way, you can use the ‘red dot’ to create new nodes, as well as the examples I demo in the video. This is a full-featured mind mapping application solution and you just can't beat the free price. " Mindmaps" is a free mindmapping html 5 web based application by David Richard. ![]() ( See also Daylight Saving Time in Canada.Galvano-Magnetic 24 Hour Clock, Royal Observatory, Greenwich. It was introduced in Canada by the federal government in 1918 as a measure for increasing war production, emulating legislation in GermanyĪnd Britain. A pre-breakfast daylight hour can be “saved” for use after supper by the practice of turning the clocks ahead by one hour in the spring and setting themīack by one hour in the autumn. In Canada, as in many middle-latitude countries, Daylight Saving Time (DST) is now commonly used. Minutes from the neighbouring time zones, as opposed to one hour. In Newfoundland, for example, the time zone differs by 30 The boundaries conform to more convenient geographical or political boundaries. For example, British Columbia time in the winter months is described as UTC-8h, meaning it is eight hours behind Coordinated Universal Time, while Newfoundland time is referred to as UTC-3h30.Ĭanada, like the rest of the world, now uses a modified version of the time zones created by Sir Sandford Fleming. Time zones in Canada are referred to as UTC- xh. Today, the implementation of Greenwich Mean Time is officially referred to as Coordinated Universal Time, or UTC. Zones around the world, each 15° of longitude wide, with the first centred on the Greenwich meridian. The conference agreed on Greenwich, England, as the common reference for longitude and time, and attending countries rapidly implemented Fleming’s plan of 24 time Fleming’s advocacy of time zones had its greatest effect in 1884 at an international conference in Washington, DC, called to select a prime meridian to be used for In 1883, North American railways adopted hour-wide time zones. Fleming became a strong advocate of time zones to be usedįor all purposes. To reduce the remaining confusion at a union station, where all the lines converged, American Charles Ferdinand Dowd advocated geographic time zones for the railways. North American railways experimented with operatingĮach line on uniform time. ![]() England was the first country to adopt standardized time, with the railways forcing the issue. William Hyde Wollaston and Abraham Follett Osler promoted a system of universal time. Although many other travellers likely had similar experiences, Fleming’s personal experience seemed to inspire his search for a way of reducing confusion He became chief engineer for the Canadian Pacific Railway, Sir Sandford Fleming spent one uncomfortable night in a railway station due to the time confusion when changing trains. However, with the advent of railways, the multitude of municipal times became a significant aggravation for travellers. Everyone agreed on this arrangement when an 18 km journey was considered long, arduous, unpredictable or rare. For example, at a latitude of 49°, two municipalities would have differed in time by one minute for each 18 km of east-west separation, with the easternmost municipality having the Up to the 1880s, municipalities used their own local mean solar time. Sir Sandford Fleming and Greenwich Mean Time ![]() The official time reference for Canada comes from the National Research Council of Canada (NRC), but, except during wartime, the provinces and municipalities legislate the official time zone boundaries. Similarly, Saskatchewan follows CST year-round and, as of 2020, Yukon follows PDT, also known as Yukon Standard Time, year-round. Boundaries shift because some municipalities choose not to participate From the second Sunday in March to the first Sunday in November most of Canada follows daylight saving time.Ī portion of northeastern British Columbia in the summer, but not during the winter (see maps below). Referred to as standard time zones, and may be abbreviated as PST, MST, CST, etc. Similarly, Saskatchewan follows CST year-round and, as of 2020, Yukon follows PDT, also known as Yukon Standard Time, year-round. For example, the Mountain time zone includesĪ portion of northeastern British Columbia in the summer, but not during the winter (see maps below). The boundaries of the standard time zones are not necessarily the same as those of the corresponding daylight saving time zones. From the second Sunday in March to the first Sunday in November most of Canada follows daylight saving time.ĭuring this summer period the time zones may be abbreviated as PDT, MDT, CDT, etc. ![]() From the first Sunday in November to the second Sunday in March these zones are From west to east these time zones are: Pacific, Mountain, Central, Eastern, Atlantic and Newfoundland. There are six time zones in Canada covering four and a half hours. ![]() Older facilities can be updated to meet 21st century needs, and NMG’s design and manufacturing efficiencies ensure the least possible amount of disruption, waste and noise. 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Apple will begin taking pre-orders for its latest premium range on September 9, with both models officially available starting September 16. You also get a 1TB option, though it will cost more money. Pricing, Availability, and ColorsĪpple has kept the pricing of the iPhone 14 Pro and iPhone 14 Pro Max unchanged from last year, as they start from $999 and $1,099, respectively. As for Pro Raw, users can capture images at 48MP, with Pro video support up to 4K 24FPS. Apple claims that it sports ‘optical quality’ thanks to the bigger sensor, but we will find out more details about this. The sensor combines four pixels into one ‘quad pixel’ so the image size remains 12MP, but it features more detail.Ī new ultrawide 3x mode is added to the mix, but the 2x option is not optical. ![]() The iPhone 14 Pro and iPhone 14 Pro Max arrive with Quad-pixel sensor technology, which is another fancy word for pixel binning. It also touts 2.44mm microns of individual pixel size with an F/1.78 aperture. Related Story Omar Sohail iPhone 14 Pro, iPhone 14 Pro Max Do Not Feature Qualcomm’s Latest 5G Modem, but Get Wider mmWave Support CameraĪpple finally upgraded from a 12MP sensor to a 48MP primary sensor, making it 65 percent larger than the previous generation. The core configuration remains unchanged compared to previous iPhone SoC launches, as you still get two high-performance cores and four power-efficiency ones. Muscle Noise and Power line Interference from raw ECG signals of different. The iPhone 14 Pro and iPhone 14 Pro Max ship with Apple’s latest and greatest A16 Bionic that is mass produced on the 4nm architecture, though Apple did not state which manufacturing partner undertook the responsibility. The use of a notch filter for power-line interference rejection, when applied. Both models also feature a Ceramic shield, but we will still advise future owners to add more protection, such as a durable case. However, the new display can deliver up to 1600 nits of brightness, and up to 2000 nits of peak brightness, like the Pro Display XDR.Īs most of you know, ProMotion technology is supported on both models, and the display can actually clock down to 1Hz to conserve battery life. Like last year’s iPhone 13 Pro and iPhone 13 Pro Max, the iPhone 14 Pro and iPhone 14 Pro Max retain the same display sizes at 6.1 inches and 6.7 inches, respectively. min Figure 3 : Power Spectrum of the raw measurement in the leakage test. Display Size, Resolution, and Other Details MAvg Notch Kaiser Che10 Moving Averez & Kaiser Fler Power. ![]() Using video in your emails is a highly engaging and entertaining way to connect with your subscribers.Ĭonsidering 64% of users are more likely to buy a product online after watching a video, you can’t argue with their effectiveness.Įven the best copy won’t succeed without strong visual design, and images can lead to significantly better email results. 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Packed with signature LEGO humor for fans of all ages, gamers will go head-to-head with the time-travelling Kang the Conqueror in this fun-filled journey spanning the Marvel Universe. This original branching storyline, co-written by award-winning comics writer Kurt Busiek, transports players into a cosmic battle across a myriad of Marvel locations ripped from time and space into the incredible Open Hub World of Chronopolis. LEGO Marvel Super Heroes 2: Deluxe Edition, LEGO Marvel Super Heroes 2. LEGO Marvel Super Heroes 2 is an all-new, epic adventure and sequel to the smash hit, LEGO Marvel Super Heroes. Its about TIME Get the Deluxe Edition now and gain access to the main game and season pass content Join your favorite Super Heroes and Super Villains. LEGO Marvel Super Heroes 2 is a Marvel Super Heroes video game released worldwide for PlayStation 4, Xbox One, Nintendo Switch and Windows PC on November. New unlockable characters Thanos, Corvus Glaive, Cull Obsidian, Proxima Midnight, Ebony Maw, Hulkbuster 2.0, and Groot ( Avengers: Infinity War) are added to the main game’s roster of over 200 Super Heroes and Super Villains. Working as a team, the menacing crew must work their way through the various levels of Attilan before they are given the opportunity to break through to Black Bolt’s throne. The Mad Titan and the Children of Thanos have invaded Attilan to take on Black Bolt and the Inhumans in an all-new original game level. ![]() Free Delivery for orders over 20 Free Click. This action-packed level offers players the chance to control Thanos, one of the most dangerous Super Villains in the Marvel Universe, and his ruthless army. Buy LEGO Marvel Super Heroes 2 Xbox One now at Smyths Toys UK Shop for Xbox One Games at great prices. ![]() Available for just $2.99, the DLC adds a level and characters from both the pages of Marvel comics and Marvel Studios’ Avengers: Infinity War. Interactive Entertainment has announced that LEGO Marvel Super Heroes 2 will be getting the Marvel’s Avengers: Infinity War Character and Level Pack. LEGO Marvel Super Heroes 2 gets Infinity War DLC |